The week in film: ‘50/50,’ ‘Margaret’ and ‘What’s Your Number?’ (video)

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The new cancer comedy ‘50/50’ from Summit Entertainment has required the distributor to walk a fine line when it comes to communicating the fairly sober plot of the film -- which stars Joseph Gordon-Levitt in the inspired-by-life story of screenwriter Will Reiser, who was diagnosed the disease at a young age -- with its uplifting spirit. Indie movie specialist Fox Searchlight has faced an arguably more fraught situation with the release of ‘Margaret,’ a film from the Oscar-nominated Kenneth Lonergan that’s taken six years to debut. Fox enters the box-office fray this weekend with ‘What’s Your Number?’ a more conventional romantic comedy starring Anna Faris and ‘Captain America’s’ Chris Evans; will the success of the summer’s breakout hit ‘Bridesmaids’ bolster its commercial prospects?

Watch Los Angeles Times reporters Rebecca Keegan and Nicole Sperling discuss the latest happenings in Hollywood.

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-- Nicole Sperling